The Journal of Phytopharmacology 2022; 11(3):142-146 ; DOI:10.31254/phyto.2022.11301
Selected Toxicity Study on Ethanolic Extract of Ocimum gratissimum (Linn.) Leaves in Letrozole-Induced Polycystic Ovarian Syndrome in Wistar Rats
Faokunla Opeyemi1 , Femi-Olabisi Fehintoluwa Joy2 , Agboola Anthonia Oluyemi3 , Ugorji Zion Kelechukwu4 , Akamo James5 , Ishola Ahmed Adebayo6 , Oladoye Odunayo7 , Alabi Tolulope Susan4
1. Department of Biochemistry, Federal University Lokoja, Kogi State, Nigeria
2. Biochemistry Unit, Department of Biological Sciences, Mountain Top University, Ogun State, Nigeria
3. Biochemistry Unit, Department of Biological Sciences, Wesley University Ondo, Nigeria
4. Biochemistry Unit, Department of Biological Sciences, Mountain Top University, Ogun, Nigeria
5. Department of Biochemistry, Federal University of Technology, Abeokuta, Nigeria
6. Central Research Laboratory, 132B, University Road, Tanke, Ilorin, Kwara State Nigeria
7. Department of Biochemistry, University of Ilorin, Ilorin, Nigeria
*Author to whom correspondence should be addressed.
Received: 4th February, 2022 / Accepted: 26th April, 2022 / Published : 5th June, 2022
Polycystic Ovarian Syndrome (PCOS) is a metabolic endocrine disorder that is common in women of reproductive age. Several synthetic drugs such as metformin are treatment options of PCOS but the side effects associated with the use of metformin have continued to limit their acceptability; Thus, necessitate the investigation of the safety of Ocimum gratissimum leaves in vivo. The toxicity of ethanolic extract of Ocimum gratissimum leaf (EEOGL) at 50 and 100mg/kg body weight dosage on PCOS was investigated in female Wistar rats. Twenty female Wistar rats with an average weight of 170.81±5.25g were allocated into 5 groups (A-E) of four animals each: group A animals (control) received distilled water while the letrozole-induced (1mg/kg body weight (B.Wt)) rats- groups B, C, D, and We were administered distilled water, co-administration of 7.14mg/kg B.Wt of metformin and 2mg/kg B.Wt of clomiphene citrate, 50mg/kg and 100mg/kg of EEOGL for 21 days respectively. The liver and kidney function indices were determined after each rat was sacrificed and blood collected by jugular puncturing. The data collected were subjected to analysis of variance and Duncan multiple range test with statistical significance set at p
Letrozole, Polycystic Ovarian Syndrome, Toxicity, EEOGL
HOW TO CITE THIS ARTICLE
Femi-Olabisi FJ, Ugorji ZK, Akamo J, Ishola AA, Faokunla O, Agboola AO. et al. Selected Toxicity Study on Ethanolic Extract of Ocimum gratissimum (Linn.) Leaves in Letrozole-Induced Polycystic Ovarian Syndrome in Wistar Rats. J Phytopharmacol 2022; 11(3):142-146. doi: 10.31254/phyto.2022.11301
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